Neurodegenerative Research

Research Scientist – New Medicines for Alzheimer’s Disease

Research Scientist – New Medicines for Alzheimer’s Disease

At Sage Bionetworks, we believe that we can learn more by learning from each other. By improving the way scientists collaborate, we help to make science more effective. We partner with researchers, patients, and healthcare innovators to drive collaborative data-driven science to improve health. Making science more open, collaborative, and inclusive ultimately advances biomedicine. 

Are you the type of person who enjoys engaging with scientists and researchers across many disciplines? Are you skilled at synthesizing scientific literature and computational data to evaluate a diverse set of disease mechanisms? Do you want to be an integral part of a team that includes computational biologist, research ethicists, software engineers, and data librarians? If so, you could be our next Research Scientist in the Neurodegenerative Research group. You will be responsible for generating reports and analyses in support of the prioritization of therapeutic hypotheses and protein targets being evaluated by the grant teams in a new medicine center that is building tools, reagents, and compounds to treat AD. You will work with researchers across diverse cores (Structural Biology, Medicinal Chemistry, Assay and Screening Core), and with external collaborators to collate evidence across genomic, genetic, imaging, prior literature, and clinical modalities. You will work to produce formal recommendations on the strength of evidence for therapeutic hypotheses, and to identify and prioritize specific protein targets associated with these hypotheses. 

What you’ll be doing: (key job responsibilities)

  • Researching and synthesizing evidence for a diverse set of putative disease mechanisms/therapeutic hypotheses for AD.
  • Identifying gaps in knowledge and working with scientists in academia and industry to identify any additional analyses required to address those gaps. 
  • Identifying and prioritizing protein targets associated with diverse therapeutic hypotheses based on literature and computational biology analyses.
  • Leading and facilitating discussions with scientists from diverse backgrounds (bioinformatics, cell biology, medicinal chemistry).  
  • Writing summaries and formal recommendations to share with the scientific steering committee and broader research community.
  • Authoring scientific papers for peer reviewed journals and presenting work at scientific conferences.

We’d love to hear from you if you: (basic skills/qualifications)

  • Are passionate about open science and collaboration
  • Have a PhD in Molecular Biology, Neuroscience or related discipline; or another scientific degree with commensurate experience.
  • Have demonstrated understanding of high dimensional genomic data, such as sequencing data, gene expression, genotype, CNV and/or data from other high-throughput biological technologies.
  • Have experience with modern experimental approaches in cell and molecular biology. 
  • Are an expert in distilling genetic and genomic findings into testable hypotheses. 
  • Demonstrate excellence in research with evidence of advancing an area of biology.
  • Have excellent written and verbal communication skills.
  • Have strong collaboration and teamwork skills.
  • Expertise in Alzheimer’s Disease or other neurodegenerative research field is preferred.

About Sage Bionetworks

Sage Bionetworks is a nonprofit biomedical research and technology development organization that was founded in Seattle in 2009. Our focus is to develop and apply open practices to data-driven research for the advancement of human health. Data-driven research has become an important component of biomedicine, but it’s not always easy to understand how to apply computational approaches appropriately or how to interpret their results. Sage believes open practices can help. Our interdisciplinary team of scientists and engineers work together to provide researchers access to technology tools and scientific approaches to share data, benchmark methods, and explore collective insights, all backed by Sage’s gold-standard governance protocols and commitment to user-centered design. Sage is supported through a portfolio of competitive research grants, commercial partnerships, and philanthropic contributions.

Sage embraces diversity, equity and inclusion. We offer a comprehensive benefits package, including relocation benefits, to bring the right talent to the team. We are based in Seattle, WA, and collaborate broadly throughout the world.

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