Neurodegenerative Research

Vice President of Computational Biology, Neurodegenerative Disease

Vice President of Computational Biology, Neurodegenerative Disease

At Sage Bionetworks, we believe that we can learn more by learning from each other. We develop and apply open practices to data-driven research for the advancement of human health. We are working to establish actionable biomedical observations through the reliable analysis and responsible sharing of representative data. By improving the way scientists collaborate and by increasing the reliability of research, we will improve human health.

We are seeking an experienced computational biologist to join Sage’s leadership team. This team works directly with Sage’s President to shape the mission of the organization and prioritize the principles and practices that we bring to all of our programs. Within this multi-disciplinary group, our research leads use their creativity to identify innovative solutions to advance biomedicine and guide our core service offerings. They then work within their groups to conduct state-of-the-art work to solve pressing problems in their field of expertise through the application of these practices. These activities establish reliable computational outputs through data and resource distribution, reproducible research practices, and through the development and benchmarking of algorithms.

Sage Bionetworks sits at the critical intersection of computational biology, translational neurodegenerative research, and open science. Your job will be to envision how we address this into the coming years. In the current portfolio, the neurodegenerative research team acts as the data and analysis coordination core across multiple, linked projects funded through the NIA Translational Research Program ( This includes programs focused on the identification of new drug targets to treat Alzheimer’s disease from large multi-omic data-sets (AMP-AD consortium), on the prioritization of genetic variants for creation of new model systems of AD and evaluation of said model systems (MODEL-AD consortium), and on the prioritization of new pathways for development of reagents and tools for drug discovery in AD (TREAT-AD consortium). These programs will provide you with a network of exceptional collaborators from academia, government and industry with expertise in neurology, bioinformatics, experimental neuroscience, and drug discovery.

Do you have a commitment to open and collaborative research practices, and an understanding of where these approaches can advance hard problems in neurodegenerative disease research? Do you have the ability to design and perform the analysis of  large molecular data-sets and interpret results? Do you want to be an integral part of a multidisciplinary team that includes computational biologists, research ethicists, software engineers, data librarians, clinical researchers, molecular biologists, and functional genomics experts? Are you passionate about leading team science endeavors? Do you agree that neurodegenerative diseases are the next frontier in computational research?

What you’ll be doing: (key job responsibilities)

  • Developing scientific strategy for collaborative research and responsible data sharing in  neurodegenerative diseases
  • Extending the computational neurodegenerative disease portfolio through initiating and securing funding through grants and/or contracts
  • Building external partnerships that align with Sage’s mission
  • Directing a team of bioinformaticians, disease experts, data scientists, program managers, and engineers in meeting project goals across programs
  • Developing and applying innovative approaches to neurodegenerative analytics and to reproducible research
  • Evangelizing and communicating about research within Sage’s portfolio and more broadly about Sage’s mission
  • Attending relevant meetings and preparing scientific manuscripts
  • Working with the leadership team at Sage to align practices across research domains and to guide roadmaps for core services shared across those domains

We’d love to hear from you if you: (basic skills/qualifications)

  • Are passionate about open science and collaboration
  • Have a PhD or other scientific degree with commensurate experience
  • Have at least 10 years of experience in computational biology or bioinformatics
  • Have at least 5 years of experience acting as principal investigator or group lead for a scientific program
  • Have postdoctoral experience with a strong publication record
  • Demonstrated evidence of leadership in large collaborative research projects
  • Have contributed to the procurement of funded research grants and/or contracts.
  • Have experience in neurodegenerative research, which is strongly preferred

In light of recent concerns of Covid-19, all interviews will be conducted remotely, and most positions will be remote through at least June 30, 2021. The option to work on-site at our Seattle office prior to June 30, will be considered upon request.

About Sage Bionetworks

Sage Bionetworks is a nonprofit health research organization that was founded in Seattle in 2009. We use open practices that increase the reliability of scientific claims to speed the translation of science to medicine. We support responsible data sharing, objective evaluation of methods and results across researchers, and the empowerment of participants to be active partners in research. Sage is a 501c3 and is supported through a portfolio of competitive research grants, commercial partnerships, and philanthropic contributions. Sage embraces diversity, equity and inclusion. We offer a comprehensive benefits package, including relocation benefits, to bring the right talent to the team. We are based in Seattle, WA, and collaborate broadly throughout the world.

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