PsychENCODE Consortium

The PsychENCODE Consortium is a collaboration between 16 institutions working to provide an enhanced framework of regulatory genomic elements in individuals with neuropsychiatric disorders.

A set of eleven manuscripts in Science, Science Translational Medicine and Science Advances is the culmination of work by the PsychENCODE Consortium to provide an enhanced framework of regulatory genomic elements in individuals with neuropsychiatric disorders.

The PsychENCODE program is funded by the NIMH with the goal of accelerating discovery of non-coding functional genomic elements in human brain, and elucidating their role in the molecular pathophysiology of psychiatric disorders. The Consortium investigators are producing a public resource of multi-dimensional genomic data using unbiased genome-wide approaches on tissue and cell-type specific samples from approximately 1000 phenotypically well-characterized healthy and diseased human post-mortem brains. The Consortium is also sharing data from functional characterization of disease-associated regulatory elements and variants in in-vitro and in-vivo model systems.