All of Us Research Program – Digital Health Technology

The mission of the All of Us Research Program is to accelerate health research and medical breakthroughs, enabling individual prevention, treatment, and care solutions. The Digital Health Technology (DHT) effort within All of Us uses technologies like mobile apps and wearable devices to measure and track aspects of lifestyle, environment, and biology. We design and deploy these DHT-based research studies in partnership with the Scripps Translational Science Institute and the All of Us Participant Technologies Service Center (PTSC) led by Vibrent Health.

Sage Bionetworks is proud to be an awardee of the AllofUS Research Program, as part of The Participant Center led by Scripps Translational Science Institute. We work on Program governance including developing the protocol, informed consent, and data governance policy, as well as supervising filings with the IRB. We also work on the Digital Health Technologies for the Program’s mobile applications.

Cardiorespiratory Fitness Module

Cardiorespiratory fitness is an important measure of general human health. As part of the National Institutes of Health (NIH) All of Us study, Sage is developing methods to use the sensors built into every modern smartphone to assess this trait in a way that can scale to potentially one  million participants, and become a generally useful tool for clinical research. Our approach relies on the smartphone camera to track heart rate changes in response to standardized exercise protocols. We are currently partnering with the Scripps Translational Research Institute and the University of San Diego to validate this approach.


MoleMapper is a personalized tool to help you map, measure, and monitor the moles on your skin. Using a familiar Maps-like interface, you can measure the size of a mole using the camera and a common reference object like a coin.

Keeping track of the size, shape and color of your moles is the best way to catch potential skin cancers like melanoma in their early stages. Whether you use Mole Mapper to keep track of a single suspicious mole over time or construct a full-body map, we hope this app will make being vigilant about your health a bit more enjoyable.

The initial release of MoleMapper™ (2.0) allowed OHSU and Sage Bionetworks to collaborate on proving the efficacy of using smartphone capabilities as a research tool empowering citizen-supported science. This resulted in a paper published in Nature’s Scientific Data journal titled, The Mole Mapper Study, mobile phone skin imaging and melanoma risk data collected using ResearchKit. In that report, we demonstrated the efficacy of using smart phones to collect data and perform relevant scientific analysis on it.

With the advent of version 3.0 for the iPhone, we are embarking on the next wave of research. We expect to generate more and better data to be used to answer many important questions. The answers to these questions will help us understand both the future capabilities and limitations of using smart phones as potential aids to patients and the medical community seeking to provide quality healthcare.



Multiple sclerosis (MS) is a neurodegenerative and progressive autoimmune disease that can bring on symptoms and relapse unexpectedly. For patients, some days are easy, while on other days MS symptoms make-up their daily story. elevateMS is an app-based study designed to characterize changes in participant-reported outcomes and functional performance tests collected on the elevateMS mobile app from participants with and without MS, in relation to disease severity and relapse.  The population is comprised of two categories: an All-comers population who may or may not have MS and a Neurologist-referred population with confirmed MS diagnosis.

elevateMS was run by Sage Bionetworks in collaboration with Novartis Pharmaceuticals Corporation. For more information, visit the elevateMS website.