The NIMH has funded the Brain Somatic Mosaicism Network (BSMN) with the goal of accelerating the discovery of somatic genomic variation across human brain cell and tissue types to explain the role of somatic mosaicism in the development of mental illnesses.
Collectively, the BSMN is examining large numbers of neurons and bulk tissue from neurotypic controls alongside matched individuals with Autism Spectrum Disorder, Bipolar Disorder, Focal Cortical Dysplasia, Schizophrenia, and Tourette Syndrome. Data are generated by whole genome and exome sequencing, and other genomic assays. These datasets are being made available to the research community, together with data exploration tools and other resources.
Use this portal to learn about the BSMN research teams and the grant projects supporting their work. Discover tools that may assist your research, and access BSMN generated data managed through the NIMH Data Archive (NDA).