Tool or Resource Type: Interactive Assessments

To complement the interactive assessments that can be incorporated into a digital health research study, Sage has used the following data collection modalities:

Fitbit

We have used Fitbit OAuth2 integration in our study apps to connect to Fitbit’s Partner-level API to collect intraday sleep, activity, and heart rate data

Apple Watch

Via the HealthKit API, we have used the Apple Watch (multiple series) in studies to collect data related to cardiovascular endpoints

HealthKit

Multiple of our studies have incorporated aggregated health-related data through the Apple HealthKit API

Passive Gait

Our Passive gait analysis module, implemented on iOS and Android operating systems, are able to collect passive gait data through motion sensing in the background of a participant’s phone during the day.

Life Space

This module utilizes a privacy-protecting analysis of GPS data to measure the displacement of individuals over time.

Survey-based PROs

Serving as a hallmark of many digital health studies, Sage has implemented a system to configure and deploy survey-based PROs to our digital health study apps.

The Digital Jar Open assessment measures the functional range of motion without pain for the joints of the arm (wrist, elbow, shoulder) on each arm while rotating inward and outward. Data collected from this assessment includes x,y,z accelerometer readings (at ~100Hz) and rotation rates from the gyroscope as well as the overall degrees of rotation in each direction for each arm.

Validation Status

• A validation study is in progress in the context of psoriatic arthritis.

Example studies that have used the test

 

• Psorcast (in progress)

 

Sample Data

Coming soon

The Toe Imaging assessment allows a participant to take a photo of the digits of each foot to assess symptoms related to joint swelling and nail dystrophy. Data collected include a jpeg image of each foot.

Validation Status

• A validation study is in progress in the context of psoriatic disease.

Example studies that have used the test

 

• Psorcast (in progress)

 

Sample Data

Coming soon

The Finger Imaging assessment allows a participant to take a photo of the digits of each hand to assess symptoms related to joint swelling and nail dystrophy. Data collected include a jpeg image of each hand.

Validation Status

• A validation study is in progress in the context of psoriatic disease.

Example studies that have used the test

 

• Psorcast (in progress)

 

Sample Data

Coming soon

The Joint Counting assessment allows a participant to select a given set of joints on the body for a binary yes/no as to whether each joint is affected. Data collected include the affected joints and a jpeg image summary.

Validation Status

• A validation study is in progress in the context of psoriatic arthritis.

Example studies that have used the test

 

• Psorcast (in progress)

 

Sample Data

Coming soon

The Body Area Draw assessment allows a participant to use the touch screen to draw the extent to which an area of the body is affected by a given symptom. Data collected include the calculated percentage of the body surface area and a jpeg image summary.

Validation Status

• A validation study is in progress in the context of psoriasis.

Example studies that have used the test

• Psorcast (in progress)

Sample Data

Coming soon

The Body Area Imaging assessment allows a participant to select an area of the body and use the phone camera to capture an image of this area. Data collected include the location of the body selected and a jpeg image.

Validation Status

• A validation study is in progress in the context of psoriasis.

Example studies that have used the test

 

• Psorcast (in progress)

 

Sample Data

Coming soon

The Phonation assessment is an adaption of a clinical test where a participant makes an extended “ahhhhh” sound for 20 seconds.  Data collected from this assessment includes an audio recording.

Validation Status

• Phonation has been used in multiple Parkinson’s Disease studies and has shown moderate association

Example studies that have used the test

• mPower (ClinicalTrials.gov: NCT02696603)

Sample Data

https://www.synapse.org/#!Synapse:syn11269541

The Heart Rate assessment measures the pulse of a participant using the smartphone camera and flash. The assessment monitors blood flow through the tip of the finger over the course of 20 seconds and provides quality control warnings if a heart rate is not detected. Data collected from this assessment includes heart rate estimation, a running confidence score, and summarized video pixel intensities.

Validation Status

• Validated in a 100-person cohort across all 6 Fitzpatrick skin types using 8 different phones (iOS and Android).

Example studies that have used the test

• All of Us Research Program Heart Snapshot Study. Publication in preparation.

Sample Data

Coming soon

The VO2max, or Heart Rate Recovery assessment is an adaption of the Tecumseh step test that measures VO2Max using the smartphone camera and flash. The assessment follows a protocol where participants step up and down at a fixed cadence for 3 minutes followed by monitoring of heart rate recovery for 60 seconds. Data collected from this assessment includes VO2max estimation, heart rate estimation, and summarized video pixel intensities.

Validation Status

• Validated in a cohort of 120 individuals spanning ages 20-80 by comparing to direct measurement of O2 consumption using mask and exercise protocol.

Example studies that have used the test

• All of Us Research Program Heart Snapshot Study. Publication in preparation.

Sample Data

Coming soon